Alkaline phosphates (ALP) corresponds to a group phosphates that display maximum activity at alkaline ph..ALP is widely distributed in liver, osteoblasts, intestinal epithelium, kidneys, and placentas. The rate of ALP rises physiologically for children and teenagers during periods of active growth , as well as for women during the third trimester of pregnancy. Marked increase of ALP rate are observed in case of extra hepatic obstruction (gallstones, tumours….) and bone diseases such as Pagets disease anad osteogenic bone cancer. Pal activity can also increase moderately in the event of intra-hepatic obstruction, hepatitis, cirrhosis, or along with rickets, osteomalacia, hyperparathyroidism, healing of bone fractures.